correlation between urine macrophage migration inhibitory factor (mif)/creatinine ratio and time after kidney transplantation
نویسندگان
چکیده
abstract background: despite the long-standing association of macrophage migration inhibitory factor (mif) with delayed-type hypersensitivity response, the potential role of mif in chronic allograft nephropathy is unknown. the association between upregulation of mif expression, macrophage and t cell infiltration and the severity of chronic allograft nephropathy suggests that mif may be an important mediator in the process of chronic allograft nephropathy. therefore, the aims of this study were to measure urine concentration of mif after renal transplantation, and to determine if it increases with time. methods: in this prospective cross-sectional study twenty-two pediatric patients (case, group a) who received kidney transplants between 1999 and 2006, and forty healthy children (control, group b) were recruited. urine mif and creatinine were assessed in all patients. urine mif concentrations were quantitated by elisa. results: the mean ratios of urine mif/creatinine (cr) were calculated as 5.046(sem=2.04) pg/μmol creatinine in transplanted-kidney patients (group a) and 1.85(sem=0.35) pg/μmol creatinine in healthy individuals (group b). agood significant correlation was seen between urine mif/cr ratio and time after kidney transplantation in recipients (p=0.002, rspearman = +0.633). conclusion: this study shows significant correlation between urine mif/cr ratio and time passed after transplantation. increasing mif/cr ratios were seen in patients with a longer post transplantation period. therefore, it is necessary to determine the role of macrophages in chronic renal nephropathy especially chronic rejection with additive studies and then study the effect of anti-mif antibodies in the treatment of this condition.
منابع مشابه
Correlation between urine macrophage migration inhibitory factor (MIF)/creatinine ratio and time after kidney transplantation
Abstract Background: Despite the long-standing association of macrophage migration inhibitory factor (MIF) with delayed-type hypersensitivity response, the potential role of MIF in chronic allograft nephropathy is unknown. The association between upregulation of MIF expression, macrophage and T cell infiltration and the severity of chronic allograft nephropathy suggests that MIF may be an ...
متن کاملCorrelation between urine macrophage migration inhibitory factor (MIF)/creatinine ratio and time after kidney transplantation
Background: Despite the long-standing association of macrophage migration inhibitory factor (MIF) with delayed-type hypersensitivity response, the potential role of MIF in chronic allograft nephropathy is unknown. The association between upregulation of MIF expression, macrophage and T cell infiltration and the severity of chronic allograft nephropathy suggests that MIF may be an important medi...
متن کاملMacrophage Migration Inhibitory Factor in Clinical Kidney Disease
Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine implicated in acute and chronic inflammatory conditions, including sepsis, autoimmune disease, atherogenesis, plaque instability, and pulmonary arterial hypertension. MIF in plasma and urine is significantly elevated in patients with acute kidney injury (AKI) and elevated MIF in serum is associated with markers of oxidat...
متن کاملAssociation between macrophage migration inhibitory factor rs1007888 and GDM.
We investigated the association between macrophage migration inhibitory factor (MIF) rs1007888 single-nucleotide polymorphisms and the genetic susceptibility to gestational diabetes mellitus (GDM). A total of 240 GDM pregnant women (GDM group) and 330 healthy pregnant women (control group) were included in the study. Differences in the MIF rs1007888 genotype and allele frequencies and differenc...
متن کاملSerum macrophage migration inhibitory factor (MIF) levels after allogeneic hematopoietic stem cell transplantation.
Macrophage migration inhibitory factor (MIF) may play an important role in the pathogenesis of acute graft-versus-host disease (aGVHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT), as MIF plays an important role to regulate the production of tumor necrosis factor-alpha (TNF-alpha), one of the inflammatory cytokines which induces and exacerbates aGVHD. We examined the ass...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
medical journal of islamic republic of iranجلد ۲۲، شماره ۲، صفحات ۵۵-۶۲
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023